Chapter 653
Chapter 626 He feels that results are about to come
Professor Qu is very particular about washing his hands. He first washes with soap and at the same time carefully brushes with a small brush. The folds of the skin are the key areas for scrubbing. After washing, wipe with iodine, and rub with alcohol.
Professor Qu turned off the faucet instead of the palm of his hand, but the elbow. The purpose of this operation is to avoid re-contamination of germs on the white palm.
Shen Qi copied and pasted Professor Qu’s hand-washing operation. He washed and said: “To be honest, the medical laboratory of our center is indeed in the process of employing people. At this stage, it is mainly engaged in the research and development of chemical drugs. Medicine is extremely important. A huge and complex subject includes more than just chemistry.”
“Chemical drug synthesis is a very applied scientific research work. It is not difficult to dig out some applied elite talents. It is difficult to dig for scholars in basic medical theory research. Chinese students go abroad to study, and basically no one learns this major. Foreign nationals It’s also difficult for researchers of basic medical theory to come to China to work. Personally, I attach great importance to basic theoretical work, whether it’s mathematics, physics, chemistry, biology or medicine. So Lao Qu, we should increase our efforts to cultivate local people. Researcher of basic medical theory.”
“The engineer who does the synthesis of medicine is the engineer. The master who does the research on the basic theories of medicine.” Shen Qi turned off the faucet with a elbow, and then returned to the office with Professor Qu.
“Director Shen, you have said so much, it is nothing more than a person. As I said earlier, you can take away these students. You can also take away, including me.” Professor Qu was very generous.
“Then it’s settled.”
“Lead and lead are lead away.” Professor Qu waved his hand and agreed.
Shen Qi looked around, but couldn’t find what he wanted: “Old Qu, don’t you have coffee here?”
“As a medical worker who has been working for 30 years, I suggest you drink less coffee and more boiled water.” Professor Qu poured a glass of boiled water and handed it to Shen Qi: “Director Shen, you said that you are a master who is doing basic medical research. I strongly agree with me. I have studied anemia for many years, such as thalassemia and Fanconi anemia. I have studied all of these diseases, and I have achieved a little bit of small results. Let’s say thalassaemia major, it is a genetic disease, treatment The plan is not complicated, blood transfusion, iron removal. In more severe cases, the spleen is removed, or stem cell transplantation.”
“Type R anemia is not hereditary, but the disease is more complicated, much more complicated than thalassaemia. The best medicine on the market is this capsule of GLK, but you and I all know that this medicine is very expensive, but The fundamental problem cannot be solved. It can only be said that the quality of life of patients will be slightly improved by taking GLK medicine. Patients will be more painful if they do not take this medicine. We also want to do gene activation therapy, but there is no new medicine in this area. Without new drugs, even the best clinicians can’t come up with a better treatment plan. Director Shen, I have a general understanding of the LPJK1 project of your center. I heard that LPJK1 is a gene activation therapy drug?”
“Yes.” Shen Qi nodded.
Professor Qu asked: “You haven’t entered the animal experiment yet, right?”
“almost.”
“I hope you can succeed, save a life, and have a lot of merit. By the way, how is your wife’s health?”
“The same way.” Shen Qi took a photo of Professor Pai Qu’s document and said: “Can I make a copy of the observation records of these patients with type R anemia and take them back for study?”
“of course.”
“Thank you, then I will leave first.”
The purpose of Shen Qi’s visit to the hospital has been achieved. He returned to the center and convened all the members of the chemical laboratory for a meeting.
Shen Qi told Professor Qu that the engineers who do drug synthesis are the masters who do basic theoretical research.
It is such a rationale. If scholars who study basic medical theories produce results, they are basically rushing for the Nobel Prize in Medicine. Those who do drug synthesis also have a chance to win the Nobel Prize, but the compulsion is definitely not as high as the basic theory.
Compared with other fields, the pharmaceutical industry has the highest technical requirements. There is no shortage of Nobel Prize winners among internationally renowned pharmaceutical companies. They have gone from the academic world to the industrial application world, and they do not have much difference. They are also medical academic research, and medical theory is transferred to applied research.
In many other fields, academia and industrial applications are basically divided. People who study mathematics leave the academia to work in investment banking, people who study the microstructure of materials to build new energy vehicles, and people who study computers do everything. .
The academic circles look down on the profiteering of the industrial application circles, thinking that they are corrupted by sugar-coated shells.
Those in the industrial application circle can’t get used to the high-mindedness and stubbornness of the academic circle. Of course it’s money.
This kind of contradiction also exists in Shen Qi and his center.
This kind of contradiction in the Chemical Pharmaceutical Laboratory of the Shen Qi Scientific Research Center is the most shallow. In the field of drug research and development, academic research and engineering applications are closely linked, and the division is not obvious.
“LPJK1 has entered a critical stage, everyone will work hard for a while and make a few more samples.” After the meeting, Shen Qi entered the chemistry laboratory and conducted experiments with the researchers.
“The 0202nd experiment of LPJK1 used azatriazole and 1,3-dithiane as starting materials to carry out the S rearrangement reaction…” He Lin became the main operator unwillingly.
The S rearrangement reaction was invented by Shen Qi. The international chemistry community has not officially named this new type of rearrangement reaction. Researchers like He Lin call it the S rearrangement reaction for the time being.
“Heating to 200 degrees Celsius, thermal cyclization… Intermediate formation, adding malonic acid, S rearrangement again…” Assistant Cao Fan assisted Teacher He Lin, after all, he is a Ph.D. student at Yan University and has a very good understanding. Strong, he has been proficient in operating the new S rearrangement reaction in a short period of time.
Regardless of whether Newton or Leibniz invented calculus, their definitions of calculus are the same. Calculus was a new type of mathematical tool in that era to solve other mathematical or physical problems.
The S rearrangement reaction invented by Shen Qi is also a tool. Of course, the academic significance of the S rearrangement reaction cannot be compared with calculus. After all, there are too many organic synthetic names reactions.
“The final product should be an eight-membered heterocyclic ring I hope the yield can be higher… Photocatalysis, side chain removal…” Cao Fan did his experiments with ease, and Shen Qi nodded in praise.
LPJK1 project achieves this stage, it is not only a rare anemia drug synthesis project.
The purpose of this project is to develop a type R anemia drug with high yield, low side effects and significant curative effect. In the development process, new things such as new rearrangement reactions and stable synthesis of macrocyclic compounds are incorporated.
New rearrangement reactions, macrocyclic compounds, these contents are very academic, while drug synthesis belongs to engineering applications.
Facts have proved that academic research and engineering applications are very closely integrated in top chemical pharmaceutical laboratories.
To synthesize a new drug requires not only a profound academic theory researcher, but also a skilled engineering application operator.
The LPJK1 experiment is still progressing intensively and orderly. Shen Qi sits in the laboratory, and he feels that results are about to come out.