I Just Want to Be a Quiet Top Student

Chapter 672 Shen Nuofei

Ou Ye’s patient crawled on the ground like a reptile, shouting: “I like to sleep with female students. I have slept with more than 60 female students. Hahahaha! What about sleeping? What can you do to me? Those female students can’t even write papers, but it doesn’t matter, as long as they sleep with me, I will let them graduate. Ah ha ha ha, what can you do to me?”

Professor Qu shouted: “He Yuankai, enough!”

The patient suddenly hugged Professor Qu’s thigh and wept loudly: “Professor Qu, I am a patient. You have to explain the situation to them. I am a seriously ill patient. They can’t take me away! I want to stay in the hospital, I want to Cure!”

Professor Qu waved his hand: “Take him away!”

The crazy patient was taken away, Shen Qi couldn’t help being alert, and Ou Ye had a disgusted expression on his face.

“Old Qu, what’s the situation with this He Yuankai? I remember, he seems to be a subject in a triazaoctene clinical trial? He has a mental problem? It shouldn’t be a side effect of the drug, right?” Shen Qi said Nervous, triazaoctene has finally progressed to the phase i clinical stage. If there are mental side effects, it will be over!

“He is pretending to be crazy and selling stupid.” Professor Qu shook his head. “This person is a teacher in the university. I just received the news that he was being investigated for embezzling project funds for embezzlement.”

Shen Qi sighed, and at the same time filled with righteous indignation: “Damn! How can such a morally corrupt person recruit him into the test group?”

Lao Qu looked up at the gorgeous sunset in the sky at an angle of 45 degrees, and said deeply: “In the eyes of doctors, there are only patients and non-patients.”

Ou Ye was indignant: “What is this surname, what a scum! He was investigated for embezzlement of public funds, and he slept with so many female students, is there no one to care about it?”

Shen Qi said: “Students can’t write papers or fail the exam. They go to the teacher to beg for letting go. This kind of thing is not uncommon in some universities. A few years ago, I published a paper on mathematical analysis. 80 of the students in the college failed, and some failed students begged me to give me a little more… This is uncontrollable, the teacher did not force the students, the students took the initiative to send them to the door…”

Ou Ye pinched Shen Qi by the waist: “Shen Qi, I allow you to organize the language to speak again.”

Shen Qiyi said rightly: “Take care, you must manage, you must manage! Other places are not under my control, but at Yanda University, I must take care of it. Since then, the academy has never invited me to be a student of mathematics. I have the test paper. I haven’t published it for several years.”

Ou Ye asked, “I remember the tragedy of the sub-subjects, and in the end it seemed that only 30 students died, and the remaining 50, you let it go?”

Shen Qi: “I have added a few points to those with a real score of 50 or more. It is not easy for students to come to Yan University, and the questions I posed that time were really difficult.”

Ou Ye was wary: “Did the girl student fall asleep?”

Shen Qi waved his hands again and again: “No, no! All men who came to me begged me. The doctoral students I brought were all men.”

“Oh.”

“Old Qu, let’s talk about business matters and go to your office.” Shen Qi asked Ou Ye to return to the ward first. He and Professor Qu discussed medical issues together.

After the tolerability test of a new drug in Phase I clinical trials, it is the pharmacokinetic and pharmacodynamic test.

Triazaoctene is currently advanced to the pharmacokinetic and pharmacodynamic test stage. At this stage, the research team uses pk to study the absorption, distribution, metabolism, excretion and time process of the drug in the subject, and through p research Time course of drug action.

Through pkp and related mathematical methods, combined with clinical observations, the phase i clinical data of triazaoctene has begun to emerge.

Including Ou Ye, there are a total of 60 phase i clinical subjects.

As the husband of Ou Ye, Shen Qi is most concerned about the tolerance and pharmacodynamic index of triazaoctene in Ou Ye.

As the developer of triazaoctene, Shen Qi also needs to pay full attention to the clinical performance of these 60 subjects, including previous animal experimental data, and subsequent phase ii and phase iii clinical trials.

Whether a new drug can be marketed depends on its safety and efficacy in the vast majority of target subjects.

Of course, Shen Qi hopes that triazaoctene will eventually be marketed, and his focus has gradually shifted to other subjects.

Professor Qu showed to Shen Qi that the pharmacokinetics model established based on 60 subjects is currently a semi-finished product and needs to be supplemented with data, but some trends can also be seen.

“Tmax and cmax are obtained through actual measurements, and ac0t is obtained through trapezoidal calculation. We use 2 to find the estimated values ​​of t12 and actinf. This is a non-compartmental model, which is pharmacokinetics, bioequivalence, and bioavailability. The main pharmacokinetic calculation method in the research is also the statutory calculation method in the new drug declaration.”

“However, the parameters obtained by the non-compartmental model are sometimes difficult to use to establish a pk prediction model and perform pkp correlation analysis. Therefore, in this clinical trial, we also used the compartment model and performed rigorous mathematical analysis. Director Shen, you see This is sample 6. After the drug enters the body of sample 6, the drug is distributed to the target point, and after binding to the target point, it produces pharmacological effects, which causes physiological and pathological changes, thereby bringing about clinical therapeutic effects.”

“Sample 6 has very good data, who is this?”

“Sample 6 is your wife.”

“Oh, it’s not bad, it’s quite 6. But sample 27, it doesn’t seem ideal.”

“Sample 27 is He Yuankai, the university teacher who pretended to be crazy just now.”

“Look at the overall model analysis.”

“The overall model has not been done yet, but it’s okay. Let’s take a look at the process data. You see, Director Shen, we use lcmsms analysis. Within the range we set, the relationship between the drug concentration and its signal response is determined by a weighted linear regression function. To describe, you can also use binomial to describe…”

“Old Qu, get out of the way, I’ll help you describe it in binomial style.”

Shen Qi volunteered to undertake the calculation and analysis of the mathematical model. After more than half an hour, he completed the binomial description of the overall model.

Compared with the weighted linear regression function description, the binomial description reveals a more detailed relationship between the drug concentration and its signal response.

“The Philippine Award winners are really different.”

The phase i clinical trial of triazaoctene has reached the final stage. The main work at this stage is data analysis and processing, and finally a written report is formed. Research teams and clinical teams declare new drugs or publish papers. They all speak with data and use written reports to determine research results.

Shen Qishun helped Professor Qu made a binomial description, which accelerated the data processing progress of the clinical team.

It can be seen from the existing data that, considering the maximum, minimum, and average values, there is great hope for triazaoctene to pass the phase i clinical trial.

Following the publication of the official paper on Ou Ye’s strong bs conjecture, many mathematics teams around the world announced that they have carried out the interpretation and verification of the strong bs conjecture.

These mathematical teams include the Bargava team from the Clay Institute, the Gong Changwei team from Columbia University, the Linden Strauss team from the Weizmann Institute in Israel, the Adama team from Oxford University, the Su Wenxie team from Mizuki University, and the Tao Zhexuan team…

The explanation and verification of the strong bs conjecture seems to have formed an academic competition.

Formal academic institutions and well-known mathematicians on all continents in Europe, America, and Asia have taken action, and folk sciences around the world are not far behind.

A retired mathematics teacher from Ouye High School’s alma mater declared on a video website with huge traffic: “After my verification, Ouye’s strong bs conjecture is established. Don’t thank me, this is what I should do.”

There is no proof that the retired mathematics teacher showed a few verification manuscripts in the video, which looked so professional.

At the end of the video, the retired math teacher said: “Come to the mathematics class for young talents, help your child get the Olympic math gold medal, and recommend a success rate of 98 to famous schools!”

“It turned out to be advertising!” Netizens vomit one after another.

There are also netizens who think: “In these years, advertising for training courses also requires technical content. At least the verification manuscript of this math teacher is very professional.”

Folk Crouching Tiger, Hidden Dragon, maybe there are really peerless masters like sweeping monks.

There is no doubt that Teacher Liu, the instructor of the Pomegranate Mathematics Class of Experiment 2 is a master.

Teacher Liu is a PhD in mathematics from Fudan University. He is an officer of the Chinese Mathematical Society and used to be the coach of the algebra class of the Chinese National Olympic Team.

Teacher Liu is very experienced in mathematics competitions. He is a meritorious coach and has trained many imo perfect score gold medalists such as Shen Qi and Zhou Yu’an, helping the Chinese Olympic Mathematics team to dominate the imo team championship for five consecutive years.

Doctor of mathematics from a prestigious school, secretary of the Chinese Mathematical Society, meritorious coach of the National Mathematical Olympiad… With such a remarkable experience, why would Teacher Liu be willing to serve as the instructor of an elite mathematics class in a primary school?

There must be a shocking secret hidden in it.

“Shen Nuofei, can you solve this equation?” Teacher Liu knocked on the blackboard in the small classroom. He was not a teacher establishment of the second experimental elementary school. He was a highly-paid instructor hired by the second experimental elementary school.

There is only one student in the small classroom She is Shen Nuofei.

Arranged by the Mathematics Teaching and Research Group of the Second Elementary School, when Shen Nuofi, a student in the first class, would go to the small classroom to receive the careful guidance of Teacher Liu from the pomegranate math class.

The equation on the blackboard is 12357

This one-dimensional first-degree equation is the teaching content of the fifth grade. For most primary school students in the first grade, this question is definitely beyond the outline.

But for Shen Nuofei, Chaogang is normal.

A week ago, this question was super outline.

Now, Shen Nuofei has mastered the core technology of one-dimensional linear equations under the tutoring of Teacher Liu.

Shen Nuofei nodded and said, “Teacher Liu, I can do this.”

Teacher Liu handed a piece of chalk to Shen Nuofi: “Come on, you write the steps to solve the equation on the blackboard. If you give the correct answer, then we will immediately enter the teaching link of multiple equations.” (https://)