NOVEL WEB I can see the status bar
Chapter 1179 New Challenge
Chapter 1179 New Challenge
The alveolar damage mechanism of the new coronavirus is a topic that everyone is paying attention to. It is not surprising that Shen Xi has thoughts about it.
What really interested Sun Lien was the "reappearance" later.
Alveolar cell damage is irreversible, which is a medical consensus that is basically equivalent to common sense.However, unlike myocardial regeneration, human alveoli still have the possibility of regeneration-type II lung epithelial cells (AT2 cells) are the key points that determine alveolar regeneration.
As one of the most important alveolar cells that form and maintain tissue, type II lung epithelial cells also have the ability to differentiate into type I lung epithelial cells (AT1 cells).In other words, type II lung epithelial cells may be stem cells of type I lung epithelial cells.
The reason why type II lung epithelial cells are not directly identified as stem cells of type I lung epithelial cells is because the cells themselves have functions related to the regulation of alveolar water and the metabolism of pulmonary surfactant—after all, the concept and definition of stem cells It is still developing, but it is not yet possible to simply define type II lung epithelial cells as stem cells.
The alveolar cell regeneration discovered this time is an obvious example of transformation from type II lung epithelial cells to type I lung epithelial cells.
The researchers stained lung specimens from two patients infected with the novel coronavirus who underwent lung transplantation.Stained by hematoxylin and eosin (H&E).Subsequently, it was found that there were many exfoliated cell clusters and hyaline membranes in the alveolar spaces of the samples, and there were obvious fibrotic features in the interstitial area-this indicated that both patients had severe diffuse alveolar damage.
As a study of injury, this content can only be regarded as a supplement to the existing cognition.But what they found later was surprising—there was a large number of type I lung epithelial cell loss and type II lung epithelial cell clumping in the samples.
In aggregated type II lung epithelial cells, the researchers observed proliferation.
The aggregation and proliferation of type II pulmonary epithelial cells are not of much clinical significance, but this is a very obvious signal - the human body is a very stingy Grandet, it is almost impossible to waste energy and nutrients to proliferate a batch Useless cells.Such proliferation must have a purpose.
By measuring three markers (CLDN4, SFN and KRT8) that differentiate type II lung epithelial cells into type I lung epithelial cells, the researchers found that these three markers, which rarely appear in the lungs of healthy people, were abundant Appeared in the lungs of patients with novel coronavirus pneumonia.This clearly shows that there is a process of differentiation of type II lung epithelial cells into type I lung epithelial cells in the lungs of patients with pneumonia infected by the new coronavirus.
No matter from which point of view, this can be clearly called "alveolar cell regeneration".
To put it bluntly, such a discovery is as exciting as the Berlin patient who recovered from HIV.Although it is not yet certain what causes the regeneration of type I lung epithelial cells in these patients, it at least gives a direction for researchers in all related fields-alveoli can be regenerated, and the principles and mechanisms of this regeneration If only scientists could figure it out...
Then pulmonary fibrosis will no longer be an incurable disease.
Sun Lien was a little emotional and a little excited.
If such progress could be discovered a few years earlier, maybe Dean Wu would be able to... live a healthy and healthy life for more than ten years.Instead of being short of breath and feeling oppressed every day when life enters the terminal stage.
Sun Lien, who has experienced the feeling of being out of breath, understands how uncomfortable it is to be depressed better than anyone else.
"You do it well." Although he thought a lot, Sun Lien gave Shen Xi's request quickly and directly, "No matter what resources the Respiratory Research Institute wants, as long as they want it, as long as we have it, we will give it to them."
"You are the big boss, you have the final say." Shen Xi reluctantly agreed.Although these monkeys and resources, the experimental group is also very greedy.But... After all, it was Sun Lien who made it, not to mention that this is his laboratory.
Shen Xi fully trusts Sun Lien's ability to manage resources, as long as Sun Lien is around, these "things outside the body" can always be "returned after all the money is gone".What's more, the scientific research ability of the Hu Research Institute is indeed strong enough.At that time, it will not be difficult to bring Shen Xi and Sun Li'en, or even the entire experimental group, to publish eight high-scoring SCI articles.
Compared to this, he is now more concerned about Sun Lien's isolation.
"When will you...be released after serving your sentence?" Shen Xi asked on the other end of the phone, "I remember you've been here for more than ten days, right?"
"Twelve days." Sun Lien sighed, "A day is like a year."
Doing nothing for twelve days is very exhausting, and it is also exhausting to be dead busy for twelve days.Sun Li'en now wanders back and forth between doing nothing and being too busy to die every day, but his life is quite comfortable.
After all, the main job is to communicate with people on the phone.This is completely acceptable to Sun Li'en - it's just that his voice feels a little uncomfortable on the phone every day.
What really made Sun Lien feel uncomfortable was the sense of separation that they never saw each other after they were separated from Hu Jia.
Not long after arriving at Yunhe, the two teamed up again.Although according to the relevant system and epidemic prevention regulations, the two cannot live in the same room...but at least they can see each other every day.Sun Li'en could always see Hu Jia's big bright eyes through the face screen and goggles.
In the end, when he returned to Ningyuan, he couldn't see Hu Jia anymore.
This feeling is very difficult.Especially after Sun Lien had just experienced the longest two months with Hu Jia.
For two months, the two could see each other almost every day.Although they are separated by protective clothing, although both of them are dressed like Dabai in the movie.But, after all, you can see the above every day.
This is already much stronger than when he was in Ningyuan.
Sun Li'en felt that he might be suffering from Hu Jia's withdrawal syndrome.
Be patient, be patient.Lying on the bed tossing and turning, Sun Lien comforted himself repeatedly.In another four days, he would be able to hug Hu Jia in front of everyone, turn around several times, and then kiss him hard.
Then the two of them can go home together, continue to kiss and the rest of the matter - Dean Song has ordered that everyone have a seven-day holiday after returning home.Normal schedules resume after seven days.
If it weren't for the sake of the seven-day vacation... Sun Lien took a deep breath, then sighed and smiled wryly.
Then you have to isolate!
·
·
·
"When are you going to tell him?" Wang Caifeng was sitting in her office, her eyes were crying like rotten peaches.
"What's the use of hiding this kind of thing? Does he still have to know eventually?" Wang Caifeng said anxiously because the answer on the other end of the phone was not positive enough, "Don't hide it, tell him quickly. Li En is Doctor, he may have a way..."
"May I beg you?" Wang Caifeng said, tears came down again, she quickly wiped her eyes, and continued to persuade, "Otherwise, after Lien is quarantined, how can I tell him?"
"Anyway, don't make a diagnosis for yourself." At this point, Wang Caifeng's tone became tough again, "You are not a doctor! I run a hospital and I don't know this yet? En came out, I let him come to treat you!"
"Listen to me, you're right!" Wang Caifeng ended her speech in the most resolute tone, "I'll call Sun Li'en right now, and you can send me all the information... Sister-in-law, our family is not helpless. I will take care of your illness!"
The first day in Haikou...
I had a great chat with several authors, and my saliva drools enviously after hearing the achievements they talked about.
(End of this chapter)
The alveolar damage mechanism of the new coronavirus is a topic that everyone is paying attention to. It is not surprising that Shen Xi has thoughts about it.
What really interested Sun Lien was the "reappearance" later.
Alveolar cell damage is irreversible, which is a medical consensus that is basically equivalent to common sense.However, unlike myocardial regeneration, human alveoli still have the possibility of regeneration-type II lung epithelial cells (AT2 cells) are the key points that determine alveolar regeneration.
As one of the most important alveolar cells that form and maintain tissue, type II lung epithelial cells also have the ability to differentiate into type I lung epithelial cells (AT1 cells).In other words, type II lung epithelial cells may be stem cells of type I lung epithelial cells.
The reason why type II lung epithelial cells are not directly identified as stem cells of type I lung epithelial cells is because the cells themselves have functions related to the regulation of alveolar water and the metabolism of pulmonary surfactant—after all, the concept and definition of stem cells It is still developing, but it is not yet possible to simply define type II lung epithelial cells as stem cells.
The alveolar cell regeneration discovered this time is an obvious example of transformation from type II lung epithelial cells to type I lung epithelial cells.
The researchers stained lung specimens from two patients infected with the novel coronavirus who underwent lung transplantation.Stained by hematoxylin and eosin (H&E).Subsequently, it was found that there were many exfoliated cell clusters and hyaline membranes in the alveolar spaces of the samples, and there were obvious fibrotic features in the interstitial area-this indicated that both patients had severe diffuse alveolar damage.
As a study of injury, this content can only be regarded as a supplement to the existing cognition.But what they found later was surprising—there was a large number of type I lung epithelial cell loss and type II lung epithelial cell clumping in the samples.
In aggregated type II lung epithelial cells, the researchers observed proliferation.
The aggregation and proliferation of type II pulmonary epithelial cells are not of much clinical significance, but this is a very obvious signal - the human body is a very stingy Grandet, it is almost impossible to waste energy and nutrients to proliferate a batch Useless cells.Such proliferation must have a purpose.
By measuring three markers (CLDN4, SFN and KRT8) that differentiate type II lung epithelial cells into type I lung epithelial cells, the researchers found that these three markers, which rarely appear in the lungs of healthy people, were abundant Appeared in the lungs of patients with novel coronavirus pneumonia.This clearly shows that there is a process of differentiation of type II lung epithelial cells into type I lung epithelial cells in the lungs of patients with pneumonia infected by the new coronavirus.
No matter from which point of view, this can be clearly called "alveolar cell regeneration".
To put it bluntly, such a discovery is as exciting as the Berlin patient who recovered from HIV.Although it is not yet certain what causes the regeneration of type I lung epithelial cells in these patients, it at least gives a direction for researchers in all related fields-alveoli can be regenerated, and the principles and mechanisms of this regeneration If only scientists could figure it out...
Then pulmonary fibrosis will no longer be an incurable disease.
Sun Lien was a little emotional and a little excited.
If such progress could be discovered a few years earlier, maybe Dean Wu would be able to... live a healthy and healthy life for more than ten years.Instead of being short of breath and feeling oppressed every day when life enters the terminal stage.
Sun Lien, who has experienced the feeling of being out of breath, understands how uncomfortable it is to be depressed better than anyone else.
"You do it well." Although he thought a lot, Sun Lien gave Shen Xi's request quickly and directly, "No matter what resources the Respiratory Research Institute wants, as long as they want it, as long as we have it, we will give it to them."
"You are the big boss, you have the final say." Shen Xi reluctantly agreed.Although these monkeys and resources, the experimental group is also very greedy.But... After all, it was Sun Lien who made it, not to mention that this is his laboratory.
Shen Xi fully trusts Sun Lien's ability to manage resources, as long as Sun Lien is around, these "things outside the body" can always be "returned after all the money is gone".What's more, the scientific research ability of the Hu Research Institute is indeed strong enough.At that time, it will not be difficult to bring Shen Xi and Sun Li'en, or even the entire experimental group, to publish eight high-scoring SCI articles.
Compared to this, he is now more concerned about Sun Lien's isolation.
"When will you...be released after serving your sentence?" Shen Xi asked on the other end of the phone, "I remember you've been here for more than ten days, right?"
"Twelve days." Sun Lien sighed, "A day is like a year."
Doing nothing for twelve days is very exhausting, and it is also exhausting to be dead busy for twelve days.Sun Li'en now wanders back and forth between doing nothing and being too busy to die every day, but his life is quite comfortable.
After all, the main job is to communicate with people on the phone.This is completely acceptable to Sun Li'en - it's just that his voice feels a little uncomfortable on the phone every day.
What really made Sun Lien feel uncomfortable was the sense of separation that they never saw each other after they were separated from Hu Jia.
Not long after arriving at Yunhe, the two teamed up again.Although according to the relevant system and epidemic prevention regulations, the two cannot live in the same room...but at least they can see each other every day.Sun Li'en could always see Hu Jia's big bright eyes through the face screen and goggles.
In the end, when he returned to Ningyuan, he couldn't see Hu Jia anymore.
This feeling is very difficult.Especially after Sun Lien had just experienced the longest two months with Hu Jia.
For two months, the two could see each other almost every day.Although they are separated by protective clothing, although both of them are dressed like Dabai in the movie.But, after all, you can see the above every day.
This is already much stronger than when he was in Ningyuan.
Sun Li'en felt that he might be suffering from Hu Jia's withdrawal syndrome.
Be patient, be patient.Lying on the bed tossing and turning, Sun Lien comforted himself repeatedly.In another four days, he would be able to hug Hu Jia in front of everyone, turn around several times, and then kiss him hard.
Then the two of them can go home together, continue to kiss and the rest of the matter - Dean Song has ordered that everyone have a seven-day holiday after returning home.Normal schedules resume after seven days.
If it weren't for the sake of the seven-day vacation... Sun Lien took a deep breath, then sighed and smiled wryly.
Then you have to isolate!
·
·
·
"When are you going to tell him?" Wang Caifeng was sitting in her office, her eyes were crying like rotten peaches.
"What's the use of hiding this kind of thing? Does he still have to know eventually?" Wang Caifeng said anxiously because the answer on the other end of the phone was not positive enough, "Don't hide it, tell him quickly. Li En is Doctor, he may have a way..."
"May I beg you?" Wang Caifeng said, tears came down again, she quickly wiped her eyes, and continued to persuade, "Otherwise, after Lien is quarantined, how can I tell him?"
"Anyway, don't make a diagnosis for yourself." At this point, Wang Caifeng's tone became tough again, "You are not a doctor! I run a hospital and I don't know this yet? En came out, I let him come to treat you!"
"Listen to me, you're right!" Wang Caifeng ended her speech in the most resolute tone, "I'll call Sun Li'en right now, and you can send me all the information... Sister-in-law, our family is not helpless. I will take care of your illness!"
The first day in Haikou...
I had a great chat with several authors, and my saliva drools enviously after hearing the achievements they talked about.
(End of this chapter)
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