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Chapter 1162 Breaking News
Chapter 1162 Breaking News
The phone call between Sun Lien and Professor Enrico lasted for two hours, and the communication across the ocean finally came to an end.
The main reason preventing the two from continuing to communicate is still a matter of time.It was almost noon on the Italian side, and Professor Enrico had to replace his colleagues who were on the night shift before.
The two-hour communication benefited Professor Enrico a lot. He thanked Sun Lien and the Red Cross Society of China for their assistance many times, and made a request—ask the Red Cross Society of China to provide an English version of the new coronavirus Guidelines for the diagnosis and treatment of viral pneumonia.
"The front-line staff lack time to read the relevant literature, and we have no time to observe and reproduce the hypotheses proposed by the relevant research." Professor Enrico said helplessly, "The research content will be handed over to other research doctors to follow up. , what we need is a guide that can be used as soon as possible.”
The part of the guide can only be handled by comrades in relevant departments-Sun Lien does not have the time in France to translate such a long guide into English.
And when Sun Lien was about to end the meeting, the feedback from Italy finally arrived.That guy who popped up in the video conference earlier... he really wasn't Professor Giuseppe.Instead, he worked as a reporter for a newspaper named after a famous western financial center.
"How did he obtain Professor Giuseppe's account, we have already handed it over to the police for investigation." The staff of the Italian Red Cross apologized in English with a thick accent, "We have no experience in organizing video conferences. , This incident was indeed caused by our negligence, and I'm really sorry for wasting Dr. Sun's time."
It's good to have the right attitude.Sun Li'en nodded. He personally scolded him anyway, and once he apologized, the rest of his anger almost disappeared.However, there was one thing that he felt needed to be mentioned.
"I read on the news that the first case of pneumonia reported by Italy with a new type of coronavirus infection has no history of living in China, and has no contact with Chinese tourists." Sun Lien reminded, "If this is indeed the case, there is It is necessary to carry out large-scale PCR examination and whole genome sequencing of the patients currently infected with these new coronaviruses in Italy."
What Sun Lien is most worried about is that the relationship between the new coronavirus that is spreading wildly in Italy and the new coronavirus that is currently spreading in Yunhe is not that great.
The work of tracing the origin of the new coronavirus... not surprisingly, the progress is extremely slow.After all, the work of tracing the origin of the SARS virus lasted for more than ten years, and the final conclusion of the origin tracing was not completed until around 18 years ago.But it is not an isolated case of a new virus suddenly appearing in the human field of vision.Every virus has its natural host, and under normal circumstances, the virus will complete its transmission and prevalence in its natural host, which is "normal".
And this normality is occasionally a little abnormal - just like other organisms that develop genetic mutations and then evolve.The original virus mutated during the process of replicating in the original host.For a virus with an extremely simple structure, such a mutation can have a huge impact.For example, a virus can parasitize a new host and start multiplying.
The occasional ability to parasitize new hosts doesn't necessarily pose a threat to humans -- and sometimes it doesn't even pose a threat to new hosts.But the novel coronavirus has apparently mutated into a form that... has never been seen before.
Its structure and genome structure are highly similar to the SARS virus. It is difficult to say whether the new coronavirus made a comeback after the mutation of the SARS virus, or shared the same ancestor with the SARS virus.And to figure this out, scientific collaboration on a global scale is crucial.
Sun Lien's proposal to the Italian side was for this purpose.The source of the epidemic in Italy is a mystery, and Sun Lien is even more worried that it is not the new type of coronavirus that is spreading in Italy that is killing the Quartet.
The first locally diagnosed patient with pneumonia caused by a new type of coronavirus in Italy is not directly related to Yunhe.In terms of time and space, the patient had never been to Yunhe, or had contact with Yunhe residents.Then, if we find out what and who the patient was infected with, we may be able to find the source of the epidemic.
In the face of a respiratory-borne epidemic, the most cost-effective way is to extinguish the epidemic directly in the bud.When the first patient is found, medical isolation should be carried out for all his contacts, and then PCR testing should be performed on all of them to screen out the cause of the infection of the first patient.
In this way, the entire Italian medical system may need to receive a few or a dozen patients, and about 2000 people need to be isolated and observed.
But the virus has spread and tragically killed more than 600 people in Italy.Now it is impossible to separate the at-risk groups from the general public through epidemiological investigations.Today, there is only one way to control the epidemic—to copy China’s epidemic prevention measures and treat the whole of Italy, especially the most severely affected Lombardy region, as a crane.
Whether it is collection of receivables, home isolation, grassroots mobilization, or shelter hospital policies, each strategy has played a vital role in extinguishing the epidemic in Yunhe.A huge city cannot eliminate infectious diseases without a firm public health strategy.
A firm public health strategy needs to be based on the right data and knowledge.If the new coronavirus circulating in Italy is different from the new coronavirus in Yunhe, then many strategies in the epidemic prevention and treatment process may not have such good effects.
At least the current strategy of the Italian government, which currently recommends only people caring for people with respiratory symptoms, and health care workers caring for respiratory symptoms, to wear masks is confusing.And it clearly declares that the general population without respiratory symptoms does not need to wear masks.
The customary regulations that doctors should wear masks under any circumstances have been simplified to "caring for patients with respiratory symptoms", which makes Sun Lien very puzzled.Even in the face of the flu, adopting such a strategy is a kick in the head.
Could it be that the Italian Ministry of Health thinks that a distance of one meter between people is enough because the virus strains that are prevalent in Italy are different from the ones that are prevalent in Yunhe?
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·
·
Sun Lien was a little worried about the epidemic situation in Italy, and after the meeting, Sun Lien received a call from Xiao Linfeng—this made him even more worried.
"Dr. Sun, I have a... unconfirmed, and probably will not be recognized by any official department in the future to share with you." On the phone, Xiao Linfeng's voice sounded a bit ethereal, and there was a There were rhythmic murmurs, and most importantly, Xiao Linfeng's tone sounded anxious.
"Tell me." Sun Lien frowned and said, "What's the news?"
Xiao Linfeng is an old fox, and a very smart old fox.As the helm of the entire Takeda Pharmaceutical, it is impossible for him to suddenly call himself for no reason, and then share a gossip.
There must be something going on here.
What Xiao Linfeng said was also very exciting. He whispered, "Didn't we get the PCR kit manufacturing method for the new coronavirus from Dr. Sun before? Our branches in the United States and Italy are synchronously carrying out reagents. The manufacturing and experimental work of the kit. The accuracy of the kit is good, and the current accuracy rate is about 80%.”
"This is a good thing." Sun Li'en said with some uncertainty, this accuracy rate is very close to the accuracy of the PCR detection kit currently in use nationwide by Yuhua Biotech.
"The next part is gossip." Xiao Linfeng said with a sigh, "In order to test the true effectiveness of this batch of kits, the Italian branch used more than 30 of their existing oropharyngeal swab samples for testing. Among them, we found that a four-year-old girl living near Milan had a positive sample collected on December 12 last year."
Sun Li'en froze for a moment, then said in shock, "What?!"
The news was so frightening that Sun Lien had to wonder if the Italian branch of Takeda Pharmaceuticals had made a mistake.You must know that Yunhe's first confirmed case of pneumonia caused by a new type of coronavirus was diagnosed on December 12, and the patient had never been to that seafood market.
The first case in Italy was even three days earlier than Yunhe's case?
"This is just the first part of the gossip." Xiao Linfeng didn't seem to hear Sun Lien's shock at all. He continued, "The scarier part is yet to come."
“我们在美国的分社检查了从去年12月13日到今年1月17日，美国九个州的7389个血液样本，这些样本都是无偿献血者捐献血液之前留下的样本。所有的九个州的样本里，试剂盒的检测都有阳性反应。12月13日在加州、华盛顿和俄勒冈州的106份样本里，抗体都是阳性反应。”
"I'm just a businessman, and I don't know what the data and results mean. I only know that the data is not normal, and as a senior partner and scientific advisor of our society, it is necessary for you to know this data." Xiao Linfeng said on the phone The other end coughed twice, "That's it, I still have things to do here, so I'll hang up first."
Listening to the busy tone of "beep beep" coming from the mobile phone suddenly, Sun Lien froze in shock.
Things in Italy aside, but the news from the United States is really... scary.
According to Xiao Linfeng, they found in a survey in the United States that among the more than 12 samples collected on December 13 last year, 7000% of the samples showed positive results for the new coronavirus nucleic acid.
To make a comparison, compared with the population size of 1000 million people, it is assumed that all residents of Yunhe City are subjected to an ideal random spot check in one test.So the positive rate of the new coronavirus nucleic acid in Yunhe's samples should be around 0.49%.
According to the 1.4% calculation, on December 12 last year, the number of confirmed patients with the new coronavirus in the United States should be around 13 million.
This statistic was so explosive that Sun Li'en sat down on the ground and didn't recover for a long time.
PS The papers mentioned in the article are available for download in the book friend group
The data mentioned in this paper come from: Basavaraju SV, Patton ME, Grimm K, et al. Serologic Testing of US Blood Donations to Identify Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-Reactive Antibodies: December 2019-January 2020. Clin Infect Dis. 2021;72(12):e1004-e1009. doi:10.1093/cid/ciaa1785
(End of this chapter)
The phone call between Sun Lien and Professor Enrico lasted for two hours, and the communication across the ocean finally came to an end.
The main reason preventing the two from continuing to communicate is still a matter of time.It was almost noon on the Italian side, and Professor Enrico had to replace his colleagues who were on the night shift before.
The two-hour communication benefited Professor Enrico a lot. He thanked Sun Lien and the Red Cross Society of China for their assistance many times, and made a request—ask the Red Cross Society of China to provide an English version of the new coronavirus Guidelines for the diagnosis and treatment of viral pneumonia.
"The front-line staff lack time to read the relevant literature, and we have no time to observe and reproduce the hypotheses proposed by the relevant research." Professor Enrico said helplessly, "The research content will be handed over to other research doctors to follow up. , what we need is a guide that can be used as soon as possible.”
The part of the guide can only be handled by comrades in relevant departments-Sun Lien does not have the time in France to translate such a long guide into English.
And when Sun Lien was about to end the meeting, the feedback from Italy finally arrived.That guy who popped up in the video conference earlier... he really wasn't Professor Giuseppe.Instead, he worked as a reporter for a newspaper named after a famous western financial center.
"How did he obtain Professor Giuseppe's account, we have already handed it over to the police for investigation." The staff of the Italian Red Cross apologized in English with a thick accent, "We have no experience in organizing video conferences. , This incident was indeed caused by our negligence, and I'm really sorry for wasting Dr. Sun's time."
It's good to have the right attitude.Sun Li'en nodded. He personally scolded him anyway, and once he apologized, the rest of his anger almost disappeared.However, there was one thing that he felt needed to be mentioned.
"I read on the news that the first case of pneumonia reported by Italy with a new type of coronavirus infection has no history of living in China, and has no contact with Chinese tourists." Sun Lien reminded, "If this is indeed the case, there is It is necessary to carry out large-scale PCR examination and whole genome sequencing of the patients currently infected with these new coronaviruses in Italy."
What Sun Lien is most worried about is that the relationship between the new coronavirus that is spreading wildly in Italy and the new coronavirus that is currently spreading in Yunhe is not that great.
The work of tracing the origin of the new coronavirus... not surprisingly, the progress is extremely slow.After all, the work of tracing the origin of the SARS virus lasted for more than ten years, and the final conclusion of the origin tracing was not completed until around 18 years ago.But it is not an isolated case of a new virus suddenly appearing in the human field of vision.Every virus has its natural host, and under normal circumstances, the virus will complete its transmission and prevalence in its natural host, which is "normal".
And this normality is occasionally a little abnormal - just like other organisms that develop genetic mutations and then evolve.The original virus mutated during the process of replicating in the original host.For a virus with an extremely simple structure, such a mutation can have a huge impact.For example, a virus can parasitize a new host and start multiplying.
The occasional ability to parasitize new hosts doesn't necessarily pose a threat to humans -- and sometimes it doesn't even pose a threat to new hosts.But the novel coronavirus has apparently mutated into a form that... has never been seen before.
Its structure and genome structure are highly similar to the SARS virus. It is difficult to say whether the new coronavirus made a comeback after the mutation of the SARS virus, or shared the same ancestor with the SARS virus.And to figure this out, scientific collaboration on a global scale is crucial.
Sun Lien's proposal to the Italian side was for this purpose.The source of the epidemic in Italy is a mystery, and Sun Lien is even more worried that it is not the new type of coronavirus that is spreading in Italy that is killing the Quartet.
The first locally diagnosed patient with pneumonia caused by a new type of coronavirus in Italy is not directly related to Yunhe.In terms of time and space, the patient had never been to Yunhe, or had contact with Yunhe residents.Then, if we find out what and who the patient was infected with, we may be able to find the source of the epidemic.
In the face of a respiratory-borne epidemic, the most cost-effective way is to extinguish the epidemic directly in the bud.When the first patient is found, medical isolation should be carried out for all his contacts, and then PCR testing should be performed on all of them to screen out the cause of the infection of the first patient.
In this way, the entire Italian medical system may need to receive a few or a dozen patients, and about 2000 people need to be isolated and observed.
But the virus has spread and tragically killed more than 600 people in Italy.Now it is impossible to separate the at-risk groups from the general public through epidemiological investigations.Today, there is only one way to control the epidemic—to copy China’s epidemic prevention measures and treat the whole of Italy, especially the most severely affected Lombardy region, as a crane.
Whether it is collection of receivables, home isolation, grassroots mobilization, or shelter hospital policies, each strategy has played a vital role in extinguishing the epidemic in Yunhe.A huge city cannot eliminate infectious diseases without a firm public health strategy.
A firm public health strategy needs to be based on the right data and knowledge.If the new coronavirus circulating in Italy is different from the new coronavirus in Yunhe, then many strategies in the epidemic prevention and treatment process may not have such good effects.
At least the current strategy of the Italian government, which currently recommends only people caring for people with respiratory symptoms, and health care workers caring for respiratory symptoms, to wear masks is confusing.And it clearly declares that the general population without respiratory symptoms does not need to wear masks.
The customary regulations that doctors should wear masks under any circumstances have been simplified to "caring for patients with respiratory symptoms", which makes Sun Lien very puzzled.Even in the face of the flu, adopting such a strategy is a kick in the head.
Could it be that the Italian Ministry of Health thinks that a distance of one meter between people is enough because the virus strains that are prevalent in Italy are different from the ones that are prevalent in Yunhe?
·
·
·
Sun Lien was a little worried about the epidemic situation in Italy, and after the meeting, Sun Lien received a call from Xiao Linfeng—this made him even more worried.
"Dr. Sun, I have a... unconfirmed, and probably will not be recognized by any official department in the future to share with you." On the phone, Xiao Linfeng's voice sounded a bit ethereal, and there was a There were rhythmic murmurs, and most importantly, Xiao Linfeng's tone sounded anxious.
"Tell me." Sun Lien frowned and said, "What's the news?"
Xiao Linfeng is an old fox, and a very smart old fox.As the helm of the entire Takeda Pharmaceutical, it is impossible for him to suddenly call himself for no reason, and then share a gossip.
There must be something going on here.
What Xiao Linfeng said was also very exciting. He whispered, "Didn't we get the PCR kit manufacturing method for the new coronavirus from Dr. Sun before? Our branches in the United States and Italy are synchronously carrying out reagents. The manufacturing and experimental work of the kit. The accuracy of the kit is good, and the current accuracy rate is about 80%.”
"This is a good thing." Sun Li'en said with some uncertainty, this accuracy rate is very close to the accuracy of the PCR detection kit currently in use nationwide by Yuhua Biotech.
"The next part is gossip." Xiao Linfeng said with a sigh, "In order to test the true effectiveness of this batch of kits, the Italian branch used more than 30 of their existing oropharyngeal swab samples for testing. Among them, we found that a four-year-old girl living near Milan had a positive sample collected on December 12 last year."
Sun Li'en froze for a moment, then said in shock, "What?!"
The news was so frightening that Sun Lien had to wonder if the Italian branch of Takeda Pharmaceuticals had made a mistake.You must know that Yunhe's first confirmed case of pneumonia caused by a new type of coronavirus was diagnosed on December 12, and the patient had never been to that seafood market.
The first case in Italy was even three days earlier than Yunhe's case?
"This is just the first part of the gossip." Xiao Linfeng didn't seem to hear Sun Lien's shock at all. He continued, "The scarier part is yet to come."
“我们在美国的分社检查了从去年12月13日到今年1月17日，美国九个州的7389个血液样本，这些样本都是无偿献血者捐献血液之前留下的样本。所有的九个州的样本里，试剂盒的检测都有阳性反应。12月13日在加州、华盛顿和俄勒冈州的106份样本里，抗体都是阳性反应。”
"I'm just a businessman, and I don't know what the data and results mean. I only know that the data is not normal, and as a senior partner and scientific advisor of our society, it is necessary for you to know this data." Xiao Linfeng said on the phone The other end coughed twice, "That's it, I still have things to do here, so I'll hang up first."
Listening to the busy tone of "beep beep" coming from the mobile phone suddenly, Sun Lien froze in shock.
Things in Italy aside, but the news from the United States is really... scary.
According to Xiao Linfeng, they found in a survey in the United States that among the more than 12 samples collected on December 13 last year, 7000% of the samples showed positive results for the new coronavirus nucleic acid.
To make a comparison, compared with the population size of 1000 million people, it is assumed that all residents of Yunhe City are subjected to an ideal random spot check in one test.So the positive rate of the new coronavirus nucleic acid in Yunhe's samples should be around 0.49%.
According to the 1.4% calculation, on December 12 last year, the number of confirmed patients with the new coronavirus in the United States should be around 13 million.
This statistic was so explosive that Sun Li'en sat down on the ground and didn't recover for a long time.
PS The papers mentioned in the article are available for download in the book friend group
The data mentioned in this paper come from: Basavaraju SV, Patton ME, Grimm K, et al. Serologic Testing of US Blood Donations to Identify Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-Reactive Antibodies: December 2019-January 2020. Clin Infect Dis. 2021;72(12):e1004-e1009. doi:10.1093/cid/ciaa1785
(End of this chapter)
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