I Just Want to Be a Quiet Top Student

Chapter 635 Yes i want to know

The valid recommendation period of the Nobel Prize is from September to January 31 of the following year.

Eligible referees are former Nobel Prize winners, and university professors specially designated by the Nobel Committee or the Nobel Committee.

Most of the promised winners who were still alive recommended Shen Qi to select the promised thing again.

The Nobel Committee also voted for Shen Qi, anyway, Academician Stinga voted.

In the history of the Nobel Prize, someone has rejected the literary prize, but no one has ever refused to receive the Nobel Prize in science.

As the winner of two promises, Shen Qi hopes to leave the opportunity to others. His attitude is: “Let’s go with the flow.”

On the one hand, Academician Stinga came to persuade Shen Qi to accept the award; on the other hand, he did come for academic exchanges.

“I am very sorry that I did not go to the LHC to participate in the great experiment of the black hole information paradox last year, but I read the full text of the paper on this experiment published by Professor Shen. The last LHC experiment proved that the information will not disappear after entering the black hole. . But I have a doubt. After the information processed by the wave function enters the black hole, where does it go and in what specific form does it exist?”

“Carl, do you really want to know?” Shen Qi smiled, mystery in his calm.

“There is a Chinese proverb, one can die at night if one hears it in the morning. Yes, I want to know.”

“You are good in Chinese literature, come with me.”

Shen Qi then showed an undisclosed document.

Academician Stinga was dazed after reading it.

“Oh, it’s a pity that this is just a deduction model… If it is true, it would be great…” Academician Stinga muttered to himself, he really felt that Shen Qi was going to receive the Nobel Prize to give the Nobel Prize face.

Afterwards, Shen Qi arranged for Sha Dongdong to take Academician Stinga to eat hot pot and was shocked.

Next, Shen Qi received Academician Alexander Nelson.

Academician Nielsen is a medicinal chemist. He and his assistants are very interested in the LPJK1 project of the Shen Qi Research Center.

The LPJK1 project is doing animal experiments, and the number of its candidate active compounds is constantly decreasing. When there are 5 active compounds left, major pharmaceutical companies including GLK are investigating the relevant situation of the Shenqi Research Center.

Not only pharmaceutical companies, some academic institutions are also paying attention to the latest developments in Shen Qi’s laboratory. For example, a group of scholars like Academician Nelson of the Royal Swedish Academy of Sciences.

“Professor Shen, can we visit your medicinal chemistry experiment?” Academician Nelson asked.

“Of course.” Shen Qi led his Swedish friends into the laboratory.

The Central Chemistry Laboratory is currently on half-off. Most of the researchers have gone home for the Chinese New Year. Only Cao Fan, a PhD student, sticks to the post to clean.

The active compounds of the LPJK1 project have been sent to the Tongzhou Animal Experimental Base for animal experiments. Twenty-two active compounds have been continuously eliminated in the animal experiment link, and there are currently 5 remaining.

The laboratory is no longer busy, quiet and peaceful.

If Academician Nelson and the group proposed to visit the laboratory two months ago, Shen Qi would really not agree.

Now, just visit it.

Academician Nielsen took a look at the left and right, and said: “Professor Shen, we have seen reports on 22 macrocyclic compounds synthesized in your laboratory in the patent report. We are very excited, so I immediately flew to China and thought Have an in-depth communication with you.”

When applying for a compound patent, a rough synthetic route is usually attached, but patent applicants often do not give a complete synthetic route when applying for a patent.

Twenty-two compounds in the LPJK1 project of Shen Qi Research Center have applied for patents. Like most patent inventors, they did not give a complete synthesis route.

The LPJK1 project has innovated some important chemical methods in the process of preparing active compounds.

The 17 eliminated compounds have caused certain side effects on animals, but these 17 compounds and the remaining 5 are stable in chemical structure and chemical properties.

Twenty-two compounds are all eight-membered heterocyclic compounds, macrocyclic compounds

Under normal circumstances, macrocyclic compounds are unstable and can exist in the process of chemical reactions, but it is difficult to obtain a stable final product. Because of the instability of macrocyclic compounds, organic reactions on macrocyclic compounds are rarely developed.

This is also the main purpose of Academician Nielsen’s visit: “We all know that five-membered and six-membered rings are the most stable, and most chemically synthesized drugs are also five-membered and six-membered rings. The HIV drug darunavir, medicinal chemists will naturally think of the Paterno-Buchi reaction, or the Aldol reaction, which plays a key role in another synthesis route.”

“Huh huh.” Shen Qi nodded, agreeing deeply.

Academician Nelson continued: “During the development of the prostate drug Sultan, Pfizer has designed many synthetic routes, and the core reactions supporting each synthetic route are different. In the end, Pfizer chose the Wittig reaction as the core synthesis. Route, because the raw material price of this route is the cheapest. Five-membered ring and six-membered ring drugs have formed a very complete set of chemical synthesis system, and a variety of name reactions have been developed. The synthetic route of eight-membered ring drugs , The core reaction involved is almost impossible to find.”

Shen Qi: “Yes, it’s like this.”

Compared with Shen Qi’s calmness, Academician Nielsen became more and more excited when he said: “Your chemical drug R&D team seems to have given a new idea You take the newly developed rearrangement reaction as the core and get Twenty-two kinds of stable eight-membered heterocyclic active compounds! I would like to know whether there is a general rule to synthesize stable eight-membered ring compounds or even larger ring compounds with a new rearrangement reaction as the core? Can you share the complete synthetic routes of 22 macrocyclic compounds and the complete theoretical system supporting this synthetic route?”

“Professor Shen, your synthesis route in the patent report is too simple? Now that you have applied for a patent, can we get a sneak peek and see the more complete research results? Or, can you In academic journals, publish the latest research results of macrocyclic compounds as soon as possible? Oh, Professor Shen, in my opinion, your research results can be combined with the’discovery and development of the diene synthesis method’ and the development of the organic synthesis The olefin metathesis method is on par.”

Academician Nelson spoke generously, and Shen Qi hehe smiled noncommittal.

Bystander Cao Fan’s heart is turbulent, **** it? Discovered and developed the diene synthesis method, and developed the olefin metathesis method in organic synthesis… These research results are all of the Nobel Prize in Chemistry!

But it’s no fuss to think about it. Director Shen made a Nobel Prize achievement, which is also a routine operation.